Harald Steiner Selected Research

Peptide Hydrolases (Proteases)

1/2024	Cleavage efficiency of the intramembrane protease γ-secretase is reduced by the palmitoylation of a substrate's transmembrane domain.
1/2023	Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site.
1/2023	Membrane lipid remodeling modulates γ-secretase processivity.
1/2022	Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis.
1/2022	Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2.
1/2020	Photo-controlled delivery of very long chain fatty acids to cell membranes and modulation of membrane protein function.
1/2020	Substrate recruitment by γ-secretase.
1/2016	Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.
3/2015	Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process.
6/2010	Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.

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Harald Steiner Research Topics

Disease

65	Alzheimer Disease (Alzheimer's Disease) 01/2024 - 06/2002
5	Neoplasms (Cancer) 01/2024 - 05/2010
5	Amyloid Plaque 10/2008 - 12/2003
3	Dementia (Dementias) 12/2019 - 03/2015
3	Carcinoma (Carcinomatosis) 01/2018 - 01/2013
1	Pituitary Neoplasms (Pituitary Adenoma) 01/2024
1	Glioblastoma (Glioblastoma Multiforme) 10/2022
1	Chronic Disease (Chronic Diseases) 10/2022
1	Smith-Lemli-Opitz Syndrome 01/2021
1	Myoclonus (Nocturnal Myoclonus) 12/2019
1	Seizures (Absence Seizure) 12/2019
1	Atherosclerosis 01/2019
1	Schizophrenia (Dementia Praecox) 01/2016
1	Parkinson Disease (Parkinson's Disease) 07/2015
1	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2015
1	Neoplasm Metastasis (Metastasis) 12/2014
1	Teratocarcinoma 01/2013
1	Cognitive Dysfunction 08/2009

Drug/Important Bio-Agent (IBA)

51	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2024 - 06/2002
30	Proteins (Proteins, Gene)FDA Link 01/2024 - 06/2002
28	Amyloid beta-PeptidesIBA 06/2010 - 06/2002
20	Amyloid (Amyloid Fibrils)IBA 01/2023 - 04/2011
18	Peptide Hydrolases (Proteases)FDA Link 01/2024 - 06/2002
14	Peptides (Polypeptides)IBA 01/2023 - 08/2009
12	PresenilinsIBA 01/2022 - 06/2002
8	Aspartic Acid ProteasesIBA 05/2009 - 10/2002
5	Membrane Proteins (Integral Membrane Proteins)IBA 01/2024 - 05/2003
5	AcidsIBA 06/2010 - 01/2007
3	Presenilin-1IBA 01/2020 - 04/2008
3	Epithelial Cell Adhesion MoleculeIBA 01/2018 - 01/2013
2	EnzymesIBA 01/2020 - 01/2016
2	Amino Acids FDA Link 12/2019 - 01/2016
2	4- (N- methylamino)- 4'- (2- (2- (2- fluoroethoxy)ethoxy)ethoxy)stilbeneIBA 01/2015 - 01/2014
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2022
1	Chimeric Antigen ReceptorsIBA 10/2022
1	Cell Surface ReceptorsIBA 10/2022
1	CytokinesIBA 10/2022
1	LigandsIBA 10/2022
1	MicellesIBA 01/2022
1	Lipid Bilayers (Lipid Bilayer)IBA 01/2022
1	SteroidsIBA 01/2021
1	Membrane LipidsIBA 01/2020
1	Flavin-Adenine Dinucleotide (FAD)IBA 01/2020
1	Donepezil (Aricept)FDA LinkGeneric 12/2019
1	Oxidized LDL ReceptorsIBA 01/2019
1	LectinsIBA 01/2019
1	Bexarotene (LGD1069)FDA Link 01/2018
1	valylleucineIBA 01/2016
1	AntigensIBA 10/2015
1	SynucleinsIBA 07/2015
1	Glycoproteins (Glycoprotein)IBA 01/2013
1	Amiodarone (Amiodarona)FDA LinkGeneric 06/2010
1	Bepridil (Vascor)FDA Link 06/2010
1	Biomarkers (Surrogate Marker)IBA 07/2009
1	Protein Sorting Signals (Signal Peptide)IBA 05/2009
1	carprofen FDA Link 12/2006
1	Cadherins (E-Cadherin)IBA 11/2002
1	Notch ReceptorsIBA 11/2002
1	Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA 11/2002